Synthesis of Propargylamines by Cross-Dehydrogenative Coupling
نویسندگان
چکیده
منابع مشابه
Efficient and versatile synthesis of indoles from enamines and imines by cross-dehydrogenative coupling.
The indole unit is one of the most abundant and relevant heterocycles in natural products and pharmaceuticals. The synthesis of indoles has been a topic of research for over 100 years, and a variety of well-established classical methods are now available. The venerable Fischer indole synthesis, discovered in 1883, remains one of the most powerful and versatile routes to the indole heterocycle, ...
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From an interplay of UHV-STM imaging and DFT calculations, we have illustrated on-surface formation of polyphenyl chains through a hierarchical reaction pathway involving two different kinds of reactions (Ullmann coupling and cross-dehydrogenative coupling), which will provide a deeper understanding of on-surface chemical reactions and an alternative and efficient strategy to fabricate desired ...
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α-Sulfenyl ketones are potential precursors which find a variety of applications in organic synthesis. Their typical synthesis requires pre-functionalized starting materials and two to three step synthetic sequences. In addition, the selective pre-functionalization of unsymmetrical ketones is a challenge, which limits the synthesis of the desired sulfenylated ketones. To overcome these disadvan...
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The direct oxidative cross-dehydrogenative coupling (CDC) of two C H bonds can be an efficient and relatively clean strategy in organic synthesis. Various sp C Hbonds, such as benzylic and allylic C H bonds, the a-C H bonds of amines and ethers, and the C H bonds of alkanes can be oxidized for direct reaction with carbon nucleophiles. Among these reactions, the oxidation of tertiary amines to g...
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Cu(OAc)(2)-mediated dehydrogenative cross-coupling between two heteroarenes has been realized in the absence of any other additive. A mechanism involving a formal Cu(II) to Cu(0) route by convergent disproportionation of the copper mediator is proposed and has been evidenced by copper mirror formation during the reaction. This synthetic protocol provides a concise and "green" access to unsymmet...
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ژورنال
عنوان ژورنال: Current Green Chemistry
سال: 2019
ISSN: 2213-3461
DOI: 10.2174/2213346106666190916104701